Dynamics and bifurcations in a simple quasispecies model of tumorigenesis

Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least qualitatively, also allowing us to make predictions. Here we analyze a simplified quasispecies mathematical model given by differential equations describing the time behaviour of tumor cells populations with different levels of genomic instability. We find the equilibrium points, also characterizing their stability and bifurcations focusing on replication and mutation rates. We identify a transcritical bifurcation at increasing mutation rates of the tumor cells population. Such a bifurcation involves an scenario with dominance of healthy cells and impairment of tumor populations. Finally, we characterize the transient times for this scenario, showing that a slight increase beyond the critical mutation rate may be enough to have a fast response towards the desired state (i.e., low tumor populations) during directed mutagenic therapies

Magnetic field evolution and equilibrium configurations in neutron star cores: the effect of ambipolar diffusion

As another step towards understanding the long-term evolution of the magnetic field in neutron stars, we provide the first simulations of ambipolar diffusion in a spherical star. Restricting ourselves to axial symmetry, we consider a charged-particle fluid of protons and electrons carrying the magnetic flux through a motionless, uniform background of neutrons that exerts a collisional drag force on the former. We also ignore the possible impact of beta decays, proton superconductivity, and neutron superfluidity. All initial magnetic field configurations considered are found to evolve on the analytically expected time-scales towards "barotropic equilibria" satisfying the "Grad-Shafranov equation", in which the magnetic force is balanced by the degeneracy pressure gradient, so ambipolar diffusion is choked. These equilibria are so-called "twisted torus" configurations, which include poloidal and toroidal components, the latter restricted to the toroidal volumes in which the poloidal field lines close inside the star. In axial symmetry, they appear to be stable, although they are likely to undergo non-axially symmetric instabilities.Comment: MNRAS, accepte